Rohan Shah

Rohan Shah

M.D./Ph.D. Student

The University of Chicago


I am an M.D./Ph.D. student at the University of Chicago studying chromatin epigenetics in the Ruthenburg Laboratory. My research interests include developing quantitative applications of common techniques in modern molecular biology. This includes designing methods for quantitative studies of chromatin immunoprecipitation and creating novel tools for analysis of next-generation sequencing data.

Download my curriculum vitae.


  • Epigenetics
  • Antibodies
  • Chromatin immunoprecipitation
  • Next-generation sequencing


  • Ph.D. in Genetics, Genomics, and Systems Biology (ongoing)

    The University of Chicago

  • M.D. in Medicine (ongoing)

    The University of Chicago Pritzker School of Medicine

  • B.S. in Biological Chemistry with Honors, 2018

    The University of Chicago






Microsoft Excel

Adobe Illustrator

Research Experience

Student Researcher
Feb 2015 – Present Chicago, IL

Responsibilities include:

  • Developing a novel form of chromatin immunoprecipitation to quantify internal histone modifications
  • Developing methods for Bayesian reallocation of ambiguously mapped next-generation sequencing reads
  • Serving as systems administrator to manage and maintain lab servers and promote integration of computational resources with ongoing research projects throughout the lab
  • Working in multiple ongoing collaborations on the roles of histone modifications as epigenetic regulators
Chart Abstracter
The University of Chicago
May 2020 – Sep 2020 Chicago, IL
  • Worked as part of multiple ongoing research projects with Dr. Renslow Sherer at the University of Chicago.
  • Performed chart abstractions of first 414 COVID-19 admissions to the University of Chicago Medical Center
  • Worked on subgroup study examining risk factors and outcomes of COVID-19 patients with coinfections
Research Consultant
Mar 2017 – Apr 2018 Durham, North Carolina

Responsibilities included:

  • Training researchers on-site in methods and principles of calibrated chromatin immunoprecipitation
  • Consulting on feasibility of simplification and consolidation of materials and proecdures for commercialization
  • Assisting with preparing documentation and troubleshooting guides for calibrated chromatin immunoprecipitation kit

Teaching Experience

Teaching Assistant, Biological Dynamics
The University of Chicago
Mar 2021 – Jun 2021 Chicago, IL
Teaching Assistant, Molecular Biology of the Cell
The University of Chicago
Sep 2020 – Dec 2020 Chicago, IL
Peer Educator, The Human Body
The University of Chicago
Aug 2019 – Oct 2019 Chicago, IL
Teaching Assistant, Biological Dynamics
The University of Chicago
Mar 2018 – Jun 2018 Chicago, IL
Teaching Assistant, Principles of Physiology
The University of Chicago
Sep 2017 – Dec 2017 Chicago, IL
Teaching Assistant, Katen Scholars Program
The University of Chicago
Jun 2017 – Aug 2017 Chicago, IL
Teaching Assistant, Biological Dynamics
The University of Chicago
Mar 2017 – Jun 2017 Chicago, IL
Teaching Assistant, Molecular Biology of the Cell
The University of Chicago
Sep 2016 – Dec 2016 Chicago, IL
Teaching Assistant, Biological Dynamics
The University of Chicago
Mar 2016 – Jun 2016 Chicago, IL

Honors and Awards

Best Talk, UChicago Molecular Biosciences Retreat

Awarded for the best senior graduate student talk at the UChicago Molecular Biosciences Retreat.

Ting-Wa Wong MD, PhD Scholarship

Awarded to the second-year Pritzker School of Medicine student demonstrating achievement and exemplary performance in the discipline of pathology.

Growth, Development and Disabilities Training Program Appointee

Awarded full funding to pursue an M.D./Ph.D. joint degree program.

Summer Research Program Overall Excellence in Basic Sciences

Awarded to a Pritzker School of Medicine student for outstanding achievement in basic science research.

Keystone Symposia Scholarship Awardee

Awarded a scholarhip to attend and present at the Keystone Symposium on Epigenetics and Human Disease in Banff, Alberta, Canada.

Frances E. Knock Prize for Outstanding Academic Achievement in Chemistry

Awarded to a senior undergraduate at the University of Chicago for outstanding academic achievement in the Chemistry degree program.

Phi Beta Kappa Honor Society, Chapter Beta of Illinois

Inducted as a junior into the Phi Beta Kappa Honor Society.

University of Chicago Student Marshal

One of the highest honors conferred upon undergraduates at the University of Chicago, awarded for scholarship and leadership.

Katen Scholar

Chosen for an undergraduate program of education in research, health disparities, and public health.

Beatrice G. and Nate H. Sherman Fellowship

Awarded for undergraduate research at the University of Chicago.

All Publications

(2021). Re-evaluating the role of nucleosomal bivalency in early development. In bioRxiv.


(2021). Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia. In eLife.


(2021). Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads. In PLOS Comp Biol.


(2019). Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications. In Nature Protocols.


(2018). Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies. In Molecular Cell.


(2017). Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. In NSMB.